Vectorborne diseases have long been recognized to be climate driven, but it is now clear that many infectious diseases are intricately related to weather patterns, climate, and seasonality. Epidemics of cholera, a devastating disease occurring predominantly in third world countries, has been shown to be directly correlated with environmental parameters including sea surface temperature, sea surface height, and salinity, among others. Recent studies incorporating satellite sensing technology, ground truth measurements, and microbiological analyses have provided the basis for predictive modeling of cholera epidemics in Bangladesh, India, and East Africa. These findings will be discussed as a paradigm for global infectious diseases in this century.